Other than the obvious? (Any time Duke beats VT it's significant.)

Answer: It's the last home game Virginia Tech played before Frank Beamer announced his retirement.

It was Oct. 24, 2015. Duke beat VT 45-43 in four overtimes. The next week Tech went on the road and beat BC 26-10, and Frank's retirement was announced the following Sunday/Monday. The Hokies won at GT, then came home for that awful 30-27 overtime loss to the Heels in Frank's last home game.

What triggered me to come over here and post this was a comment on the Duke game report, linked below. HokieSince93 wrote:

"My take on the whole VT situation is that the overall team morale is gone. You can see it on the sidelines, the players attitudes, and the play on the field. I don’t think TALENT is the issue but rather a lack of preparation, and maybe the lack of coaches thoroughly knowing their position that they are coaching. Its been games that we have clearly been out coached, then we hear the coaches every week saying “I wish I could do that over” its becoming the norm at VT. It’s more to coaching than X’s and O’s,( and we’re not that good at coaching that either) But where’s the intensity, the passion, the swagger? I think it’s time for a change and it needs to start from the Head coach on down!"

He got his wish just a week later, and that started the process to where we are now.